Note that anxiety or tension associated with everyday stress usually does not require treatment with anxiolytics. Farmapram is used to treat patients with neurotic and neurosis-like disorders that are accompanied by feelings of anxiety and restlessness. Alprazolam may be prescribed to patients with reactive depressive states, including those developed against the background of somatic diseases.
Alprazolam may be used to treat patients with panic disorders, insomnia, and withdrawal syndrome (including alcohol and drug withdrawal syndrome).
Anxiety states, neuroses accompanied by feelings of anxiety, danger, anxiety, tension, sleep disturbance, irritability, as well as somatic disorders; mixed anxiety-depressive states; neurotic reactive-depressive states accompanied by decreased mood, loss of interest in others, anxiety, loss of sleep, decreased appetite, somatic disorders; anxiety states and neurotic depression developed on the background of somatic diseases; panic disorders in combination and without symptoms
According to various literature sources, alprazolam has a unique, in comparison with other tranquilizers, spectrum of psychotropic activity. The drug is most effective in the treatment of disorders, the clinical picture of which is predominantly defined by anxiety symptoms of varying severity. Such conditions include, first of all, panic disorder, generalized anxiety disorder, various anxiety-depressive states, including reactive and somatogenic ones. In addition, alprazolam has proven itself in the treatment of obsessive-compulsive disorder, isolated phobias, and withdrawal states.
The effectiveness of alprazolam in the treatment of panic disorder is evidenced by the results of numerous comparative studies. A number of studies indicate that in the treatment of panic disorder, compared with other benzodiazepine tranquilizers, alprazolam reduces the frequency of panic attacks to a greater extent, reduces the severity of anxiety and depressive symptoms. If partial improvement is taken into account, alprazolam is effective in 80% of cases. It is considered that in this respect the effect of alprazolam is comparable only to clonazepam. It was found that alprazolam at a mean dose of 4 to 7 mg/sug. was more effective than placebo during the 4 weeks of follow-up. At the same time, there was no direct correlation between the drug concentration in blood and the effectiveness of therapy. This means that treatment efficacy depends to a greater extent not on the drug dose, but on clinical and psychopathological factors. In addition, it is indicated that the drug acts not only on the anxiety of waiting, but also on the symptomatology of panic attacks themselves, reducing their severity and preventing the development of repeated panic attacks. The dosage range of alprazolam in the treatment of panic disorder is wider than in the treatment of other anxiety conditions and is up to 10 mg/day. (average 2-6 mg/day) divided into 3-4 doses.